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“Cell-free biocatalysis for biomanufacturing - or cell-free biomanufacturing - essentially operates enzymatic cascades without the constraints of a living cell. This is a technology that could transform the bioenergy sector but also pharma and fine chemicals,” explained Yannick Bomble, a National Laboratory of the Rockies (NLR) principal scientist and an R&D leader in cell-free biomanufacturing.
Why use living cells at all?” That’s the question researchers at the U.S. National Laboratory of the Rockies (NLR) are asking as they explore cell-free biomanufacturing—a rapidly emerging approach that replaces living microbes with precisely engineered enzyme cascades. In a new feature, NLR Principal Scientist Yannick Bomble explains why the technology could reshape not only bioenergy, but also pharmaceuticals and fine chemicals. It’s an excellent overview of why so many researchers and companies are investing in the future of cell-free manufacturing.
Recap: On June 24, eXoZymes has been awarded a $2 million Phase IIB SBIR grant from the NIH to advance the development of rare cannabinoids and novel cannabinoid analogs for drug discovery. Over the next two years, the company will use its AI-enhanced, cell-free biomanufacturing platform to expand its library of proprietary molecules, optimize production, and generate preclinical data, further validating its technology while supporting future pharmaceutical partnership and licensing opportunities.


